The Portuguese attacker has been struggling with a back injury, while the French striker has picked up a thigh problem and both will miss the upcoming trip to Munich
Cristiano Ronaldo and Karim Benzema have been left out of the Real Madrid squad that will travel to Munich to compete in the Audi Cup.
The Spanish side take on Tottenham on Tuesday in their semi-final clash on Tuesday, but are without two of their star players because of injury.
Ronaldo is suffering from a minor back injury, while Benzema has picked up a thigh injury in training.
New signing Kiko Casilla has been included in the 24-man squad, as have Danilo and Lucas Vazquez.
Norwegian teenager Martin Odegaard is also on the list.
The full squad:
Goalkeepers: Keylor Navas, Kiko Casilla, Ruben Yanez.
Defenders: Raphael Varane, Pepe, Sergio Ramos, Nacho, Marcelo, Dani Carvajal, Alvaro Arbeloa, Danilo.
Midfielders: Toni Kroos, James Rodriguez, Gareth Bale, Casemiro, Luka Modric, Denis Cheryshev, Isco, Asier Illarramendi, Asensio, Martin Odegaard.
Forwards: Jese Rodriguez, Lucas Vazquez, Borja Mayoral.